Ethyl chloroformate → 4-amino-N-[{4-[(1-(tert-butoxycarbonyl)-4-piperidinyl)methyl]-2-morpholinyl}-methyl]-5-chloro-2-methoxybenzamide

To a suspension of 4-amino-5-chloro-2-methoxybenzoic acid (27.6 g) in chloroform (200 ml) was added dropwise TEA (16.6 g) at room temperature with stirring. The internal temperature of the reaction solution was ice-cooled, and then thereto was slowly added dropwise ethyl chloroformate (16.3 g) so that the internal temperature did not rise over 5° C. After completion of addition, the mixture was stirred at internal temperature of 0 to 5° C. for 1 hour. To the reaction solution was slowly added dropwise a solution of 2-aminomethyl-4-[1-(tert-butoxycarbonyl)-4-piperidinylmethyl]morpholine (Reference Example 12) (42.9 g) in chloroform (50 ml) so that the internal temperature did not rise over 5° C., and after completion of addition, the mixture was stirred overnight without an ice bath. The reaction solution was sequentially washed with water, 5% aqueous potassium hydroxide solution, water, 5% aqueous solution of citric acid, water and brine. The solution was dried over anhydrous magnesium sulfate, and then the solvent was removed in vacuo. The residue was purified by silica gel column chromatography (eluent: ethyl acetate) to give the titled compound (32.4 g) as an amorphous solid.

1. temperaturecooled
2. customdid not rise over 5° C
3. additionAfter completion of addition
4. stirringthe mixture was stirred at internal temperature of 0 to 5° C. for 1 hour
5. customdid not rise over 5° C.
6. additionafter completion of addition
7. stirringthe mixture was stirred overnight without an ice bath
8. washThe reaction solution was sequentially washed with water, 5% aqueous potassium hydroxide solution, water, 5% aqueous solution of citric acid, water and brine
9. dry with materialThe solution was dried over anhydrous magnesium sulfate
10. customthe solvent was removed in vacuo
11. customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate)

ORDレコード

ord-aee5da9b3dcb40d198b374103a200b77

出典データセット

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07906510B2