Pyrrolidine → 4-Nitro-2-(pyrrolidin-1-yl)pyridine

HRID 602384

反応式

HRID 602384 の反応式
Cl[C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1COCC1>[N+:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:7]=1)([O-:10])=[O:9]

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 7351522-Chloro-4-nitropyridine

生成物 1

HCID 534859644-Nitro-2-(pyrrolidin-1-yl)pyridine収率 24%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

2-Chloro-4-nitropyridine (2.0 g, 12.2 mmol) was dissolved in THF (30 mL) and the solution was added with pyrrolidine (3.25 mL, 38.9 mmol), followed by stirring at 80° C. overnight. After an insoluble matter of the reaction mixture was filtered off, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80) to obtain 4-nitro-2-(pyrrolidin-1-yl)pyridine (560 mg, 24%).

後処理

  1. filtrationAfter an insoluble matter of the reaction mixture was filtered off
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80)

出典と根拠

ORDレコード
ord-eecdad9079164c198f941dc04bb20403
出典データセット
uspto-grants-2011_03
特許番号
US07906522B2

関連ノート

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