Pyridine → 2-Bromo-3-oxo-3-phenylpropanenitrile

HRID 604482ノート

反応式

HRID 604482 の反応式
[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][C:4]#[N:5].N1C=CC=CC=1.[Br:18]Br>C(Cl)(Cl)Cl>[Br:18][CH:3]([C:2](=[O:1])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:4]#[N:5]

参加物

5

反応物 3

HCID 1049PyridineHCID 24408BromineHCID 64799Benzoylacetonitrile

生成物 1

HCID 119615962-Bromo-3-oxo-3-phenylpropanenitrile

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒3 回

反応条件

温度
45 °C

実験手順

3-Oxo-3-phenylpropionitril (1.5 g, 10 mmol) was dissolved in dry chloroform (10 mL) at 0° C., and pyridine (0.81 mL, 10 mmol) was added. Bromine (4.7 mL, 10 mmol) dissolved in chloroform (4.7 mL) was added dropwise over an hour, then the reaction mixture was heated at 45° C. over night. The reaction mixture was diluted with chloroform and washed with water. The organic phases were dried over sodium sulfate and evaporated to give the crude product, which was used in the next reaction without any further purification.

後処理

  1. additionwas added dropwise over an hour
  2. washwashed with water
  3. dry with materialThe organic phases were dried over sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-435832f38ecb4b87994452347d3a1a85
出典データセット
uspto-grants-2011_03
特許番号
US07910613B2

反応ノート

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