Triethylamine → HCID 57709615、化合物

HRID 604492ノート

反応式

HRID 604492 の反応式
[NH2:1][C:2]1[S:3][C:4]([C:13]([NH:15][NH2:16])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.C(N(CC)CC)C.[C:24](N1C=CN=C1)(N1C=CN=C1)=[O:25]>O1CCCC1>[NH2:1][C:2]1[S:3][C:4]([C:13]2[O:14][C:24](=[O:25])[NH:16][N:15]=2)=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 14819492-amino-4-phenyl-1,3-thiazole-5-carbohydrazide

生成物 1

HCID 57709615HCID 57709615、化合物収率 20%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-Amino-4-phenyl-thiazole-5-carboxylic acid hydrazide (1 g, 4.3 mmol) was suspended in tetrahydrofurane (50 mL). Triethylamine (5 mL, 40 mmol) and carbonyldiimidazole (0.83, 5.1 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo. The crude product was purified by flash column chromatography, eluted with the ethyl acetate/hexanes (1/1) to give the product as a solid. Yield: 20%.

後処理

  1. customThe solvent was removed in vacuo
  2. customThe crude product was purified by flash column chromatography
  3. washeluted with the ethyl acetate/hexanes (1/1)

出典と根拠

ORDレコード
ord-0f6bc6830d7c4a508f5a3bf6d5c4a137
出典データセット
uspto-grants-2011_03
特許番号
US07910613B2

反応ノート

読み込み中…