Water → 2-(5-Oxazolyl)benzoic Acid

HRID 60601ノート

反応式

HRID 60601 の反応式
[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([O:10]C)=[O:9])=[CH:4][N:3]=[CH:2]1.[OH-].[Na+].O>C1COCC1>[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([OH:10])=[O:9])=[CH:4][N:3]=[CH:2]1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 73553912Methyl 2-(5-Oxazolyl)benzoate

生成物 1

HCID 533937912-(5-Oxazolyl)benzoic Acid収率 88.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 2-(1,3-oxazol-5-yl)benzoate (4.0 g) in THF (40 mL) was added 2 N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred at room temperature stirred for 2 days. To the reaction mixture was added water, and the mixture was washed with tert-butyl methyl ether. The pH of the obtained aqueous layer was adjusted to 2 with 2N hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate/petroleum ether to give the title compound (3.3 g)

後処理

  1. stirringstirred for 2 days
  2. washthe mixture was washed with tert-butyl methyl ether
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. washThe residue was washed with ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-61a20306c40c42c3b32fb9f85b8946b1
出典データセット
uspto-grants-2016_09
特許番号
US09440990B2

反応ノート

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