1-Chloro-4-(trifluoromethyl)benzene → 4-Methoxy-4'-trifluoromethyl-biphenyl

反応式

COc1ccc(B(O)O)cc1.FC(F)(F)c1ccc(Cl)cc1>C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.C1COCCO1.CC(C)(C)P(C1CCCCC1)C(C)(C)C.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Ni]>COc1ccc(-c2ccc(C(F)(F)F)cc2)cc1

参加物

反応条件

温度: 60 °C

実験手順

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

後処理

additionDilute with acetonitrile
aliquot手順は記録されていません
customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution

出典と根拠

ORDレコード: ord-ef63d8f382dc4962bce7cea114882833
出典データセット: Ni-catalyzed Suzuki Miyaura cross-coupling
DOI: 10.26434/chemrxiv.14388557.v1
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 73941-Chloro-4-(trifluoromethyl)benzene

HCID 201262(4-Methoxyphenyl)boronic acid

生成物 1

HCID 112074784-Methoxy-4'-trifluoromethyl-biphenyl収率 17%

試薬・触媒・溶媒 5

HCID 962Water試薬

HCID 62657Potassium Phosphate, Tribasic試薬

HCID 4643321Di-tert-butylcyclohexylphosphine触媒

HCID 6433264Bis(1,5-cyclooctadiene)nickel触媒

HCID 312751,4-Dioxane溶媒4 回

反応条件

温度: 60 °C

実験手順

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

後処理

additionDilute with acetonitrile
aliquot手順は記録されていません
customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution

出典と根拠

ORDレコード: ord-ef63d8f382dc4962bce7cea114882833
出典データセット: Ni-catalyzed Suzuki Miyaura cross-coupling
DOI: 10.26434/chemrxiv.14388557.v1
元リンク: 出典を表示

反応ノート

読み込み中…