反応式
[H-].[Na+].[C:3]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:4][C:5]([CH3:7])=[O:6].C(NC(C)C)(C)C.[Li].[Cl:20][C:21]1[CH:32]=[CH:31]C(C(N(OC)C)=O)=[CH:23][CH:22]=1.OS(O)(=O)=O>C1COCC1>[Cl:20][C:21]1[CH:32]=[CH:31][C:11]([C:10]2[O:9][C:3](=[O:8])[CH:4]=[C:5]([OH:6])[CH:7]=2)=[CH:23][CH:22]=1参加物
7
実験手順
The title compound (1.56 g, m.p. 247-249° C.) was prepared in a similar manner as that demonstrated in the preparation of Example N using the following: 60% NaH (0.904 g, 22.6 mmol), THF (50 mL), ethyl acetoacetate (3.00 g, 22.6 mmol), lithium diisopropylamine in THF (39.8 mL, 24 mmol), 4-chloro-N-methoxy-N-methylbenzamide (3.73 g, 22.6 mmol), 90% H2SO4 (20 mL). H NMR (300 MHz, DMSO-d6) δ11.950 (bs, 1 H), 7.878 (d, 1 H, J=9 Hz), 7.584 (d, 1 H, J=9 Hz), 6.812 (d, 1 H, J=2 Hz), 5.409 (d, 1 H, J=2 Hz).
後処理
- customthat demonstrated in the preparation of Example N
出典と根拠
- ORDレコード
- ord-fc26a3aa4682469f93b72c70a3381a26
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06005103
関連ノート
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