2-Hydroxyethyl Methacrylate → MAPTAC N-Isopropylacrylamide HEMA

HRID 613190

反応式

HRID 613190 の反応式
[Cl-:1].[CH3:2][N+:3]([CH3:14])([CH3:13])[CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:12])[C:9]([CH3:11])=[CH2:10].[CH:15]([NH:18][C:19](=[O:22])[CH:20]=[CH2:21])([CH3:17])[CH3:16].[OH:23][CH2:24][CH2:25][O:26][C:27](=[O:31])[C:28]([CH3:30])=[CH2:29]>C(O)(C)C>[CH3:11][C:9]([C:8]([NH:7][CH2:6][CH2:5][CH2:4][N+:3]([CH3:14])([CH3:2])[CH3:13])=[O:12])=[CH2:10].[Cl-:1].[CH:15]([NH:18][C:19](=[O:22])[CH:20]=[CH2:21])([CH3:17])[CH3:16].[CH3:30][C:28]([C:27]([O:26][CH2:25][CH2:24][OH:23])=[O:31])=[CH2:29]

参加物

5

反応物 3

HCID 133602-Hydroxyethyl MethacrylateHCID 16637N-IsopropylacrylamideHCID 106428Methacrylamidopropyltrimethylammonium chloride

生成物 1

HCID 131721520MAPTAC N-Isopropylacrylamide HEMA

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
75 °C

実験手順

To a 500 mL round-bottom, three-neck flask fitted with a thermocouple, reflux condenser, and septum was added 150 mL of isopropanol followed by 8.9 g of a 50% aqueous solution of N-(3-trimethylammoniopropyl)methacrylamide chloride, 15.3 g of N-iso-propylacrylamide, and 4.4 g of 2-hydroxyethylmethacrylate. The solution was purged with nitrogen for 1 hour and 0.5 g of AIBN was added. The mixture was purged for 15 min until all of the AIBN dissolved. The solution was heated to 75° C. under nitrogen for 16 hours.

後処理

  1. customTo a 500 mL round-bottom, three-neck flask fitted with a thermocouple
  2. temperaturereflux condenser
  3. customThe solution was purged with nitrogen for 1 hour
  4. addition0.5 g of AIBN was added
  5. customThe mixture was purged for 15 min until all of the AIBN
  6. dissolutiondissolved

出典と根拠

ORDレコード
ord-95ea9e826a8d42838452997224629e81
出典データセット
uspto-grants-1999_12
特許番号
US06007803

関連ノート

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