Flutamide → N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide
反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:16]([F:19])([F:18])[F:17])([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:15]=[CH:14][C:7]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:16]([F:17])([F:18])[F:19]参加物
4
実験手順
Hydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g. of 4'-nitro-3'-trifluoromethylisobutyranilide in 100 ml. of ethanol containing 0.5 g. of 5% palladium on charcoal. Filter and remove the solvent, obtaining 4'-amino-3'-trifluoromethylisobutyranilide, m.p. 114.5°-116° C.
後処理
- additionHydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g
- filtrationFilter
- customremove the solvent
出典と根拠
- ORDレコード
- ord-02a1de3a5d9142449202be4dd9fa9066
- 出典データセット
- uspto-grants-1979_03
- 特許番号
- US04144270
反応ノート
読み込み中…