HCID 22807221、化合物 → HCID 70568628、化合物

HRID 614556ノート

反応式

HRID 614556 の反応式
[O:1]=[C:2]1[N:8]2[C@H:4]([O:5][C:6]([CH:9]=[CH2:10])=[CH:7]2)[CH2:3]1.[H][H]>O1CCCC1.[Pt]>[CH:9](=[C:6]1[O:5][C@H:4]2[N:8]([C:2](=[O:1])[CH2:3]2)[CH2:7]1)[CH3:10]

参加物

5

反応物 2

HCID 22807221HCID 22807221、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 70568628HCID 70568628、化合物収率 12%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8028Tetrahydrofuran溶媒

実験手順

(5R)-7-oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0]hept-2-ene (2.4 mmole) in tetrahydrofuran (20 ml) was shaken with 5% platinum on charcoal (150 mg) under 1 atmosphere of hydrogen at room temperature for 1.5 hours. The catalyst was removed by filtration and was washed with tetrahydrofuran. The solvent was evaporated from the filtrate and the residue was chromatographed on silica gel using 1:7 ethyl acetate/petroleum ether (b.p. 60-80°). A mixture of E- and Z- isomers of the title compound was thus obtained as a colourless oil(40 mg).

後処理

  1. customThe catalyst was removed by filtration
  2. washwas washed with tetrahydrofuran
  3. customThe solvent was evaporated from the filtrate
  4. customthe residue was chromatographed on silica gel using 1:7 ethyl acetate/petroleum ether (b.p. 60-80°)
  5. additionA mixture of E- and Z- isomers of the title compound

出典と根拠

ORDレコード
ord-09d6853dacce4eba84430dd25c410755
出典データセット
uspto-grants-1979_03
特許番号
US04145430

反応ノート

読み込み中…