N-Methylbenzylamine → N-methyl N-phenylmethyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide

HRID 615393

反応式

HRID 615393 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18]([OH:20])=O)[N:9]=1.C(N(CC)CC)C.ClC(OCC)=O.[CH3:34][NH:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>C(Cl)(Cl)Cl>[CH3:34][N:35]([CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[C:18]([C:10]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:17]2[C:12]([CH:11]=1)=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:20]

参加物

6

反応物 4

HCID 7669N-MethylbenzylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 110005543-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

生成物 1

HCID 13272371N-methyl N-phenylmethyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide収率 64.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Operations are carried out as for Example 7, starting from 2.83 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.56 g of N-methyl benzylamine in 100 ml of chloroform. 2.5 g of N-methyl N-phenylmethyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide, melting at 128° C., are obtained.

出典と根拠

ORDレコード
ord-a9e8e623bf1a4e3f991d4af32214b8fe
出典データセット
uspto-grants-1985_02
特許番号
US04499094

関連ノート

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