Ethanol → 1-Acetyl-4-(2-amino-4-chlorophenyl)-2,3-dihydro-1H-pyrrole-2,2-dicarboxylic acid diethylester

HRID 616261ノート

反応式

HRID 616261 の反応式
[CH2:1]([O:3][C:4]([C:6]1([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[N+:18]([O-])=O)=[CH:8][N:7]1[C:21](=[O:23])[CH3:22])=[O:5])[CH3:2].C(O)C>O1CCCC1.CO.[Pt]>[CH2:1]([O:3][C:4]([C:6]1([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[NH2:18])=[CH:8][N:7]1[C:21](=[O:23])[CH3:22])=[O:5])[CH3:2]

参加物

6

反応物 2

HCID 702EthanolHCID 128784981-Acetyl-4-(4-chloro-2-nitrophenyl)-2,3-dihydro-1H-pyrrole-2,2-dicarboxylic acid diethyl ester

生成物 1

HCID 128785021-Acetyl-4-(2-amino-4-chlorophenyl)-2,3-dihydro-1H-pyrrole-2,2-dicarboxylic acid diethylester

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 82.2 g (0.20 mol) of the compound of Example 10 in 300 ml of tetrahydrofuran and 700 ml of methanol was hydrogenated in the presence of 4 g of 5% sulfided platinum on carbon at room temperature and 1500 psi for 22 hours. The reaction mixture was concentrated and the solid residue (76 g) was recrystallized from ethanol (320 ml) to afford 61.4 g (81%) of light orange crystals, m.p. 151.5°-153°. The analytical sample was prepared by a second recrystallization from ethanol: white crystals, m.p. 152°-153.5°.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe solid residue (76 g) was recrystallized from ethanol (320 ml)
  3. customto afford 61.4 g (81%) of light orange crystals, m.p. 151.5°-153°

出典と根拠

ORDレコード
ord-40ec0028fb15480d8cda0a7cf929959e
出典データセット
uspto-grants-1978_02
特許番号
US04073795

反応ノート

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