Pyridine → 4-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

HRID 61664

反応式

HRID 61664 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C=CC=CC=1.[N+:24]([C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)C(Cl)=O)([O-:26])=[O:25]>C(Cl)(Cl)Cl>[CH3:12][O:11][C:9]1[C:8]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([NH:1][C:34]2[CH:33]=[CH:29][CH:28]=[C:27]([N+:24]([O-:26])=[O:25])[CH:35]=2)[CH:10]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 8495Benzoyl chloride, 3-nitro-HCID 593619522-Amino-4-methoxy-5-(2-methoxyethoxy)benzamide

生成物 1

HCID 668250844-Methoxy-5-(2-methoxyethoxy)-(3-nitrophenyl)aminobenzamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a mixture of 2-amino-4-methoxy-5-(2-methoxyethoxyl)benzamide (1.78 g, 7.40 mmol) and pyridine (2.40 mL, 29.6 mmol) in CHCl3 (40 mL) was added 3-nitrobenzoyl chloride (1.44 g, 7.8 mmol). The mixture was stirred at RT for 2.5 h upon which the mixture was concentrated in vacuo to give the desired product, which was used directly in the next step without purification.

後処理

  1. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-3b92ce2d54f94a298ff3bbf4bdd5e07d
出典データセット
uspto-grants-2016_09
特許番号
US09440961B2

関連ノート

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