1-Bromohexadecane → HCID 20396833、化合物

HRID 616892ノート

反応式

HRID 616892 の反応式
[CH2:1]([C:3]1[N:7]2[CH2:8][CH2:9][CH2:10][N:11]=[C:6]2[S:5][C:4]=1[CH3:12])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[CH2:19]([Br:35])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>C(#N)C>[Br-:35].[CH2:34]([N:11]1[CH2:10][CH2:9][CH2:8][N+:7]2[C:3]([CH2:1][CH3:2])=[C:4]([CH3:12])[S:5][C:6]1=2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH3:19]

参加物

5

反応物 3

HCID 82131-BromohexadecaneHCID 10340Sodium CarbonateHCID 203968403-Ethyl-2-methyl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine

生成物 1

HCID 20396833HCID 20396833、化合物収率 18.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
0 °C

実験手順

3-Ethyl-2-methyl-6,7-dihydro-[5H]-thiazolo[3,2-a]pyrimidine (1.8 g., 0.01 mole) (prepared by basification of the hydrobromide salt with sodium carbonate) and cetyl bromide (3.3 g., 0.011 mole) were refluxed in acetonitrile solution for 16 hours. The solvent was evaporated and the residual oil solidified by stirring under dry ether at 0° C. Recrystallization from a mixture of acetonitrile and ether gave 8-cetyl-3-ethyl-2-methyl-6,7-dihydro[5H]thiazolo[3,2-a]pyrimidinium bromide, (0.92 g., 20%), m.p. 63°-66° (Found: C, 61.4; H, 9.6; N, 5.6. C25H47N2SBr requires C, 61.6; H, 9.7; N, 5.7%).

後処理

  1. customThe solvent was evaporated
  2. customRecrystallization
  3. additionfrom a mixture of acetonitrile and ether

出典と根拠

ORDレコード
ord-59c589593d914c2495d23e1d3fedf364
出典データセット
uspto-grants-1978_02
特許番号
US04076817

反応ノート

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