1-Bromooctane → 4'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

HRID 617115

反応式

HRID 617115 の反応式
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.[OH-].[Na+]>>[CH2:1]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[CH:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

4

反応物 3

HCID 81401-BromooctaneHCID 14798Sodium HydroxideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

生成物 1

HCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

反応条件

温度
70 °C

実験手順

n-Octyl bromide (0.102 mol) is added to a solution of 4-(4-hydroxyphenyl)benzoic acid (0.102 mol) and 2.5 N sodium hydroxide (0.102 mol) and the mixture stirred at 70° C. for a period of 18 hours. The reaction mixture is allowed to cool and then acidified to pH 3 and partitioned between ethyl acetate and water. The organic phase is washed with water and brine and the solvent then removed to obtain the 4'-n-octyloxy-[1,1'-biphenyl]-4-ylcarboxylic acid, C21H23O3, M.W. 326.4

後処理

  1. temperatureto cool
  2. custompartitioned between ethyl acetate and water
  3. washThe organic phase is washed with water and brine
  4. customthe solvent then removed

出典と根拠

ORDレコード
ord-1b3a60408c6b4b91a7c7f2cdc4ed6e53
出典データセット
uspto-grants-1999_09
特許番号
US05948753

関連ノート

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