反応式
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][OH:8].[H-].[Na+].Cl[C:12]1[CH:17]=[N:16][CH:15]=[CH:14][N:13]=1>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:12]1[CH:17]=[N:16][CH:15]=[CH:14][N:13]=1参加物
実験手順
(S)-(-)-1-Methyl-2-pyrrolidinemethanol (Aldrich Chemical Co., 0.5 g, 4.34 mmol) was dissolved in anhydrous THF and brought to 0° C. NaH ((80% dispersion in mineral oil), 131 g, 4.56 mmol) was added and the reaction mixture was allowed to warm to room temperature with stirring. After 30 minutes 2-chloropyrazine (0.497 g, 4.34 mmol) was added via syringe. The mixture was stirred for 48 hours. The solvent was then evaporated in vacuo and the mixture diluted with chloroform, washed with saturated NaHCO3 and a brine solution. The organic layer was then dried over MgSO4. The resulting crude material was purified by flash chromatography (10% MeOH/CHCl3) to give 0.81 g (97% yield) of the title compound as an oil. TLC Rf =0.3 (10% MeOH/CHCl3). MS (DCI/NH3) m/e 194 (M+H)+. 1H NMR (CDCl3, 300 MHz) δ: 8.24 (d, J=1.5 Hz, 1H, 8.11 (d, J=3 Hz, 1H), 8.07 (dd, J=3, 1.5 Hz, 1H), 4.36 (dd, J=9, 6 Hz, 1H), 4.28 (dd, J=9, 6 Hz, 1H), 3.16-3.08 (m, 1H, 2.7-2.58 (m, 1H, 2.47 (s, 3H), 2.34-2.24 (m, 1H, 2.08-1.93 (m, 1H, 1.91-1.67 (m, 3H).
後処理
- custombrought to 0° C
- stirringThe mixture was stirred for 48 hours
- customThe solvent was then evaporated in vacuo
- additionthe mixture diluted with chloroform
- washwashed with saturated NaHCO3
- dry with materialThe organic layer was then dried over MgSO4
- customThe resulting crude material was purified by flash chromatography (10% MeOH/CHCl3)
出典と根拠
- ORDレコード
- ord-bce61a14f88c4b30ac79a275727ce2e8
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05948793
関連ノート
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