Water → 1,2,3,6-Tetrahydro-1-methylpyridine-4-methanol
反応式
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8](OCC)=[O:9])[CH2:4][CH2:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[OH:9][CH2:8][C:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH:4]=1参加物
6
実験手順
To a solution of ethyl 1-methyl-1,2,3,6tetrahydro-4-pyridinecarboxylate (10.0 ml, 0.061 mole) in THF (200 ml) was added, maintaining temperature below 25° C., lithium aluminium hydride (2.76 g, 0.073 mole). After stirring for a further 15 min, water (2.75 ml), 10% NaOH (4 ml) and water (4 ml) were successively added, and the mixture was filtered. The filtrate was dried (Na2SO4) and evaporated in vacuo to give the title compound as an amber oil (6.30 g, 81%), which solidified on standing.
後処理
- filtrationthe mixture was filtered
- dry with materialThe filtrate was dried (Na2SO4)
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-e0115a0524324c4a8ae49617b8f1d989
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05952325
反応ノート
読み込み中…