Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one

HRID 618131

反応式

HRID 618131 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH3:12].[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH:23]=O)=[CH:15]1.N1CCCCC1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH:12]=[CH:23][C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][CH:15]=1

参加物

5

反応物 3

HCID 8082PiperidineHCID 10256Indole-3-CarboxaldehydeHCID 709912',5'-Dimethoxyacetophenone

生成物 1

HCID 541569131-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one収率 44%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 72 hours
  3. filtrationThe precipitated crystals were collected by filtration
  4. customthe obtained crude crystals
  5. customwere recrystallized from ethanol

出典と根拠

ORDレコード
ord-05fe39220067459285c6760684758e9b
出典データセット
uspto-grants-1999_09
特許番号
US05952355

関連ノート

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