HCID 21847506、化合物 → 6-Methyl-2-pyridylpropan-1-ol

HRID 618626

反応式

HRID 618626 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]#[C:10][OH:11])[CH:5]=[CH:4][CH:3]=1>CO.O=[Pt]=O>[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH2:10][OH:11])[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 21847506HCID 21847506、化合物

生成物 1

HCID 1091326-Methyl-2-pyridylpropan-1-ol収率 77%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

3-(6-methyl -2-pyridyl)propyn-1-ol was dissolved in MeOH (100 mL) and PtO2 (0.09 g) was added. The reaction mixture was hydrogenated at 4 atm for 30 min. The catalyst was filtered off and methanol evaporated in vacuo. The orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate) yielding a yellow oil (77%). MS (DCI) (M+H)+ at m/z 152.

後処理

  1. filtrationThe catalyst was filtered off
  2. custommethanol evaporated in vacuo
  3. customThe orange oily residue (2 g) was purified by column chromatography (silica gel, ethyl acetate)

出典と根拠

ORDレコード
ord-e5d6e047d2f744598b83c134f1b1aa1e
出典データセット
uspto-grants-1999_09
特許番号
US05955440

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