Tetrahydrofuran → 6-Ethyl-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

HRID 61892ノート

反応式

HRID 61892 の反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]([CH3:16])([CH3:15])[C:8](=[O:17])[CH2:7][CH2:6]2)#[CH:2].C1COCC1>C(O)C.[Pd]>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]([CH3:16])([CH3:15])[C:8](=[O:17])[CH2:7][CH2:6]2)[CH3:2]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 866638296-Ethynyl-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

生成物 1

HCID 668346966-Ethyl-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one収率 91.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

6-Ethynyl-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (346 mg) was dissolved in ethanol:THF (=2:1 mixture solvent, 20 ml), added with 10% Pd/C (170 mg), and then the mixture was stirred at room temperature for 1 hr under hydrogen atmosphere. The catalyst was removed by filtration and the organic layer was concentrated under reduced pressure to obtain the title compound (322 mg, yield 91%).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-067fa3dd93d547be81dfc72aa382c1ac
出典データセット
uspto-grants-2016_09
特許番号
US09440922B2

反応ノート

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