HCID 57174922、化合物 → (3S,4R)-3-Amino-4-phenoxyazetidin-2-one
反応式
C(OC([NH:11][C@H:12]1[C@@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23])=O)C1C=CC=CC=1.[H][H]>[Pd].C1COCC1.C(OCC)(=O)C>[NH2:11][C@H:12]1[C@@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23]参加物
6
実験手順
(3S, 4R)-3-benzyloxycarbonylamino-4-phenoxy-azetidin-2-one (1.85 g. 5.9 mmole) is hydrogenated with 2 g of 10% palladium on activated carbon in THF (30 ml) and ethyl acetate (30 ml) at 50 psi hydrogen pressure at room temperature for 2 hours. After removal of catalyst by filtration, 810 mg of deprotected (3S, 4R)-3-amino-4-phenoxy-azetidin-2-one is obtained.
後処理
- customAfter removal of catalyst
- filtrationby filtration
出典と根拠
- ORDレコード
- ord-a18e4a3b641b4570b9b5c825939a0f40
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05959123
反応ノート
読み込み中…