Thionyl Chloride → 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride

HRID 620167ノート

反応式

HRID 620167 の反応式
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[C:12]([CH3:13])=[C:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:10]=[CH:9][N:8]=1>C(Cl)(Cl)Cl>[ClH:3].[Cl:3][CH2:6][C:7]1[C:12]([CH3:13])=[C:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:10]=[CH:9][N:8]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 143061624-Pyrimidinemethanol,5-methyl-6-(1-piperidinyl)-

生成物 1

HCID 212457984-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Thionyl chloride (4.5 ml) in chloroform (30 ml) was added dropwise to a stirred solution of 4-hydroxymethyl-5-methyl-6-piperidinopyrimidine (4.24 g) in chloroform (30 ml) cooled in an ice-salt bath. The mixture was allowed to warm to room temperature and stirred for a further 22 hours. The solution was stripped to a residual glass which was triturated with diethyl ether to give 4-chloromethyl-5-methyl-6-piperidino-pyrimidine hydrochloride, 5.24 g, m.p. 182°-184°.

後処理

  1. temperaturecooled in an ice-salt bath
  2. customwas triturated with diethyl ether

出典と根拠

ORDレコード
ord-47cbc3b89caa4caaa7e580236d6fee8b
出典データセット
uspto-grants-1989_04
特許番号
US04820708

反応ノート

読み込み中…