Methyl isothiocyanate → HCID 21242849、化合物

HRID 621418

反応式

HRID 621418 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[CH3:16][N:17]=[C:18]=[S:19]>C(Cl)(Cl)Cl>[CH3:16][NH:17][C:18]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1)=[S:19]

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 135581517-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione

生成物 1

HCID 21242849HCID 21242849、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

1.3 g. (6.3 mmol) 7-Amino-4,4-dimethyl-isoquinolin-1,3-dione were dissolved in 30 ml. chloroform, mixed with 1.4 g. methyl isothiocyanate and boiled under reflux for 6 hours. The reaction mixture was then cooled and the precipitate was filtered off with suction and recrystallised from ethanol. Yield: 0.8 g. (46% of theory); m.p. 206°-207° C.

後処理

  1. temperatureunder reflux for 6 hours
  2. temperatureThe reaction mixture was then cooled
  3. filtrationthe precipitate was filtered off with suction
  4. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-92272c8f848e4bf7884f58dfbe690085
出典データセット
uspto-grants-1989_04
特許番号
US04824835

関連ノート

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