Ethyl bromoacetate → HCID 14385110、化合物

HRID 62170

反応式

HRID 62170 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][C:10]([Br:15])=[CH:9][CH:8]=3.[OH-].[K+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>CN(C)C=O.C(OCC)(=O)C>[Br:15][C:10]1[CH:9]=[CH:8][C:7]2[N:6]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:5]3[C:13]([C:12]=2[CH:11]=1)=[CH:14][C:2]([Br:1])=[CH:3][CH:4]=3

参加物

6

反応物 3

HCID 7748Ethyl bromoacetateHCID 14797Potassium HydroxideHCID 2748743,6-Dibromocarbazole

生成物 1

HCID 14385110HCID 14385110、化合物収率 96.4%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3,6-dibromocarbazole (325.0 mg, 1.0 mmol, 1 equiv) in anhydrous N,N-dimethylformamide (5 mL) was added crushed KOH (67.3 mg, 1.2 mmol, 1.2 equiv). The mixture was stirred for 30 minutes. Ethyl bromoacetate (277.2 μL, 2.5 mmol, 2.5 equiv) was added into the mixture and it was stirred at room temperature overnight. The reaction crude was diluted with ethyl acetate (30 mL) and washed with 1M HCl and water. The organic layer was dried with MgSO4 and the concentrated to afford 396.3 mg white solid as product (96.4%).

後処理

  1. stirringwas stirred at room temperature overnight
  2. customThe reaction crude
  3. washwashed with 1M HCl and water
  4. dry with materialThe organic layer was dried with MgSO4
  5. concentrationthe concentrated

出典と根拠

ORDレコード
ord-13705633f74f46e1b213b36410727bb9
出典データセット
uspto-grants-2016_09
特許番号
US09446022B2

関連ノート

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