Chloroacetonitrile → 2-(3-Methoxyiminopyrrolidin-1-yl)-2-iminoethylchloride hydrochloride
反応式
[Cl:1][CH2:2][C:3]#[N:4].[Na].Cl.[CH3:7][O:8][N:9]=[C:10]1[CH2:14][CH2:13][NH:12][CH2:11]1>CO>[ClH:1].[CH3:7][O:8][N:9]=[C:10]1[CH2:14][CH2:13][N:12]([C:3](=[NH:4])[CH2:2][Cl:1])[CH2:11]1参加物
5
実験手順
0.63 ml of chloroacetonitrile was added to a solution of 23 mg of metallic sodium in 4 ml of absolute methanol, the mixture was stirred at room temperature for about 30 minutes, then 1.5 g of 3-methoxyiminopyrrolidine hydrochloride were added and the resulting mixture stirred for a further 2 hours. After completion of the reaction, the solvent was distilled off and the concentrate mixed with anhydrous ether. The crystals which separated out were collected by filtration and washed with ether, giving 2.2 g of 2-(3-methoxyiminopyrrolidin-1-yl)-2-iminoethylchloride hydrochloride.
後処理
- stirringthe resulting mixture stirred for a further 2 hours
- customAfter completion of the reaction
- distillationthe solvent was distilled off
- additionthe concentrate mixed with anhydrous ether
- customThe crystals which separated out
- filtrationwere collected by filtration
- washwashed with ether
出典と根拠
- ORDレコード
- ord-756d2cb4878d46e4a6c00d0a0fdbe11e
- 出典データセット
- uspto-grants-1988_09
- 特許番号
- US04771046
反応ノート
読み込み中…