Sodium Hydroxide → HCID 68283363、化合物

HRID 623994ノート

反応式

HRID 623994 の反応式
[N:1]1([C:6]2[CH:7]=[C:8]([C:12]3[O:16][CH:15]=[N:14][C:13]=3[C:17]([O:19]C)=[O:18])[CH:9]=[CH:10][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C1COCC1.Cl>[N:1]1([C:6]2[CH:7]=[C:8]([C:12]3[O:16][CH:15]=[N:14][C:13]=3[C:17]([OH:19])=[O:18])[CH:9]=[CH:10][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 68283204HCID 68283204、化合物

生成物 1

HCID 68283363HCID 68283363、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of methyl 5-(3-(pyrrolidin-1-yl)phenyl)oxazole-4-carboxylate (625 mg, 2.3 mmol) in THF (223 mL) was added 1N aq. NaOH-solution (11 mL) and the resulting mixture was stirred at rt overnight. The reaction mixture was poured in 1N aq. HCl-solution and extracted with EtOAc (75 mL). The organic layer was dried (MgSO4), filtered and concentrated to dryness to afford the title compound as a white solid. LC-MS conditions A: tR=0.78 min, [M+H]+=259.00

後処理

  1. extractionextracted with EtOAc (75 mL)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-68af37ac5eed484a9c3b987ca25124b1
出典データセット
uspto-grants-2016_04
特許番号
US09303023B2

反応ノート

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