Methanol → HCID 62230337、化合物

HRID 624108ノート

反応式

HRID 624108 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:10]([NH:12][C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=1)=[O:11].CO.[OH-].[Li+]>O1CCCC1>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=1)=[O:11]

参加物

5

反応物 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 68748359HCID 68748359、化合物

生成物 1

HCID 62230337HCID 62230337、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 4-(isoindoline-2-carboxamido)benzoate (1.65 g, 5.57 mmol) was dissolved in tetrahydrofuran (30 ml) and methanol (15.00 ml) followed by the addition of lithium hydroxide (11.14 ml, 22.27 mmol) and the mixture was allowed to stir at ambient temperature over the weekend. The organic solvent was removed under vacuum, the aqueous layer was adjusted to pH ˜3 with 2N aqueous HCl, and the resulting solid was filtered with water washes to provide the title compound after drying.

後処理

  1. customThe organic solvent was removed under vacuum
  2. filtrationthe resulting solid was filtered with water

出典と根拠

ORDレコード
ord-8c7fe9ed83e84247b0878e79b93e256d
出典データセット
uspto-grants-2016_04
特許番号
US09302989B2

反応ノート

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