Sodium bis(trimethylsilyl)amide → tert-butyl 4-(6-bromo-2-oxoquinolin-1(2H)-yl)butylcarbamate
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH:6]=[CH:5]2.C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[C:23]([NH:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:34][CH2:33][CH2:32][CH2:31][NH:30][C:23](=[O:24])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[C:7](=[O:12])[CH:6]=[CH:5]2参加物
5
実験手順
To a solution of 6-bromoquinolin-2(1H)-one (430 mg, 1.91 mmol) in tetrahydrofuran (8 ml) was added sodium bis(trimethylsilyl)amide (2.1 ml, 2.08 mmol). After 15 minutes, 4-(boc-amino)butyl bromide (403 mg, 1.6 mmol) was added. The solution was stirred for 15 hours, concentrated and purified by flash chromatography to provide the title compound.