Sodium bis(trimethylsilyl)amide → HCID 68748860、化合物

HRID 624225

反応式

HRID 624225 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH:6]=[CH:5]2.C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[C:23]([NH:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:34][CH2:33][CH2:32][CH2:31][NH:30][C:23](=[O:24])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[C:7](=[O:12])[CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 2724254Sodium bis(trimethylsilyl)amideHCID 10868765tert-butyl N-(4-bromobutyl)carbamateHCID 123789436-Bromoquinolin-2(1H)-one

生成物 1

HCID 68748860HCID 68748860、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 6-bromoquinolin-2(1H)-one (430 mg, 1.91 mmol) in tetrahydrofuran (8 ml) was added sodium bis(trimethylsilyl)amide (2.1 ml, 2.08 mmol). After 15 minutes, 4-(boc-amino)butyl bromide (403 mg, 1.6 mmol) was added. The solution was stirred for 15 hours, concentrated and purified by flash chromatography to provide the title compound.

後処理

  1. concentrationconcentrated
  2. custompurified by flash chromatography

出典と根拠

ORDレコード
ord-e9c68693dd3244a891f81831e016611e
出典データセット
uspto-grants-2016_04
特許番号
US09302989B2

関連ノート

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