Hydrochloric Acid → HCID 136252344、化合物

HRID 624550ノート

反応式

HRID 624550 の反応式
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]([NH:8][CH2:9][C:10]1[CH:31]=[CH:30][C:13]2[NH:14][C:15]3[S:16][C:17]([CH3:29])=[CH:18][C:19]=3[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)=[N:21][C:12]=2[CH:11]=1)=[O:7].[Li+].[OH-].Cl>C1COCC1.O>[CH3:29][C:17]1[S:16][C:15]2[NH:14][C:13]3[CH:30]=[CH:31][C:10]([CH2:9][NH:8][C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:32])=[O:2])=[CH:11][C:12]=3[N:21]=[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[C:19]=2[CH:18]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 136377201HCID 136377201、化合物

生成物 1

HCID 136252344HCID 136252344、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of N-[2-methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulen-7-ylmethyl]-succinamic acid methyl ester, prepared as described in the previous step, (80 mg, 0.18 mmol) in THF (1.5 mL) was added LiOH (14 mg) in water (0.5 mL). The solution was stirred at room temperature for 3 h, acidified with dilute HCl, and concentrated to dryness. LC-MS: m/z 442 (M+1 of the parent).

後処理

  1. customprepared
  2. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-dc9fb150897f4cc0b7e922bf613d663e
出典データセット
uspto-grants-2016_04
特許番号
US09303041B2

反応ノート

読み込み中…