Water → 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one

HRID 625932

反応式

HRID 625932 の反応式
[CH2:1]([O:8][C:9]1[C:10](=[O:16])[NH:11][CH:12]=[C:13]([Br:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]([O-])([O-])=O.[K+].[K+].IC.O>CN(C=O)C>[CH2:1]([O:8][C:9]1[C:10](=[O:16])[N:11]([CH3:17])[CH:12]=[C:13]([Br:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 674068463-(benzyloxy)-5-bromopyridin-2(1H)-one

生成物 1

HCID 674178603-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one収率 87.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a suspension of 2.51 g (8.96 mmol) 3-benzyloxy-5-bromo-1H-pyridin-2-one and 2.48 g (17.9 mmol) K2CO3 in 45 mL DMF was added 1.12 mL (17.9 mmol) iodomethane at room temperature. After stirring overnight, 150 mL water was added with vigorous stirring causing precipitation of the product which was collected by filtration and dried in vacuo affording 2.3 g (87%) 3-benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one

後処理

  1. stirringwith vigorous stirring
  2. customprecipitation of the product which
  3. filtrationwas collected by filtration
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-6dc501ab7a7043bba1f71557da576b5b
出典データセット
uspto-grants-2016_04
特許番号
US09309199B2

関連ノート

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