Thionyl Chloride → 5-(Chloromethyl)-2-methylpyridine hydrochloride
反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][CH:3]=1.S(Cl)([Cl:12])=O>C1COCC1>[ClH:12].[Cl:12][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[N:7][CH:6]=1参加物
4
実験手順
To a solution of (6-methylpyridin-3-yl)methanol (1.24 g) in THF (12.4 mL) was added thionyl chloride (1.10 mL) under ice-cooling, and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in ethyl acetate. The precipitate was collected by filtration, and washed with ethyl acetate-hexane to give the title compound (1.64 g).
後処理
- temperaturecooling
- concentrationThe reaction mixture was concentrated under reduced pressure
- filtrationThe precipitate was collected by filtration
- washwashed with ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-2f95570a6b704641abd4e40931c3ffec
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315458B2
反応ノート
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