Dimethyl Sulfoxide → HCID 58149524、化合物

HRID 631787ノート

反応式

HRID 631787 の反応式
CS(C)=O.[I-].[CH3:6][S+](C)(C)=O.[H-].[Na+].[CH3:13][C:14]([CH3:24])([CH3:23])[C:15]([C:17]1[CH:18]=[N:19][CH:20]=[N:21][CH:22]=1)=[O:16]>O1CCCC1>[C:14]([C:15]1([C:17]2[CH:22]=[N:21][CH:20]=[N:19][CH:18]=2)[CH2:6][O:16]1)([CH3:24])([CH3:23])[CH3:13]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 24758Sodium hydrideHCID 74498Sulfoxonium, trimethyl-, iodide (1:1)HCID 136456502,2-Dimethyl-1-(pyrimidin-5-yl)propan-1-one

生成物 1

HCID 58149524HCID 58149524、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under an atmosphere of argon, 10 ml of dimethyl sulphoxide are slowly added dropwise to 0.96 g (4.3 mmol) of trimethylsulphoxonium iodide and 0.17 g of sodium hydride (60%, 4.3 mmol). The reaction mixture is then stirred at room temperature for 15 min, and 0.65 g (3.9 mmol) of 2,2-dimethyl-1-(5-pyrimidinyl)-1-propanone, dissolved in 2 ml of tetrahydrofuran, is added. The reaction mixture is stirred at 50° C. for 90 min. The reaction mixture is then concentrated under reduced pressure, and saturated aqueous sodium chloride solution and ethyl acetate are added to the residue. The organic phase is separated off dried over sodium sulphate, filtered and concentrated. This gives 0.70 g (99%) of the desired product, which is reacted without further purification.

後処理

  1. additionis added
  2. stirringThe reaction mixture is stirred at 50° C. for 90 min
  3. concentrationThe reaction mixture is then concentrated under reduced pressure, and saturated aqueous sodium chloride solution and ethyl acetate
  4. additionare added to the residue
  5. customThe organic phase is separated off
  6. dry with materialdried over sodium sulphate
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThis gives 0.70 g (99%) of the desired product, which is reacted without further purification

出典と根拠

ORDレコード
ord-59c6a7c54834445e9e8c081997c2b24f
出典データセット
uspto-grants-2016_04
特許番号
US09321732B2

反応ノート

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