Ethanol → 6-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine

HRID 633509

反応式

HRID 633509 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([S:11][C:12]#[N:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.C(O)C.SCC(C(CS)O)O.ClC1N2[N:31]=[C:32]([O:35][CH2:36][CH3:37])[CH:33]=[CH:34][C:29]2=[N:28][N:27]=1>O.P([O-])(O)(O)=O.[K+]>[CH2:36]([O:35][C:32]1[CH:33]=[CH:34][C:29]2[N:13]([C:12]([S:11][C:9]3[CH:8]=[CH:7][C:5]4[N:6]=[C:2]([NH2:1])[S:3][C:4]=4[CH:10]=3)=[N:27][N:28]=2)[N:31]=1)[CH3:37]

参加物

7

反応物 4

HCID 702EthanolHCID 190011,4-Dimercapto-2,3-butanediolHCID 816002-Amino-6-thiocyanato-1,3-benzothiazoleHCID 67524522HCID 67524522、化合物

生成物 1

HCID 425988956-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine収率 80.3%

試薬・触媒・溶媒 2

HCID 516951Monobasic potassium phosphate触媒HCID 962Water溶媒

実験手順

The 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine was prepared according to the method described in Example 17a, but using 587 mg of 2-amino-1,3-benzothiazol-6-yl thiocyanate (commercial), 20 cm3 of degassed ethanol, 13 mg of potassium dihydrogen phosphate in 0.2 cm3 of water, 1.31 g of DL-dithiothreitol and 562 mg of 3-chloro-6-ethoxy[1,2,4]triazolo[4,3-b]pyridazine. 783 mg of 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine are thus obtained in the form of a whitish powder, the characteristics of which are as follows:

後処理

  1. customThe 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine was prepared

出典と根拠

ORDレコード
ord-542b229f19334344b5bc98c618b6372f
出典データセット
uspto-grants-2016_04
特許番号
US09321777B2

関連ノート

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