Iodoethane → 1-ethylsulfanyl-4-fluorobenzene

HRID 633544ノート

反応式

HRID 633544 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.I[CH2:10][CH3:11].C(N(CC)CC)C>O1CCCC1>[CH2:10]([S:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH3:11]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 677894-Fluorothiophenol

生成物 1

HCID 53241531-ethylsulfanyl-4-fluorobenzene収率 86.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-fluorobenzenethiol (10 g, 78 mmol) and iodoethane (7.57 mL, 94 mmol) in tetrahydrofuran (100 mL) was treated with triethylamine (13.05 mL, 94 mmol) at room temperature for 2 hours. The reaction mixture was filtered and the filtrate was concentrated, washed with hexane and dried under vacuum to provide the title compound (10.5 g, 81%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. washwashed with hexane
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-1309a4d0857c4acc9f67e667b6781eb7
出典データセット
uspto-grants-2016_04
特許番号
US09321764B2

反応ノート

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