Pyridine → HCID 13187521、化合物

HRID 634711ノート

反応式

HRID 634711 の反応式
[CH:1]1([O:6][CH2:7][CH2:8][OH:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]1(C)[CH:15]=[CH:14][CH:13]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:11]=1.N1C=CC=C[CH:22]=1>>[C:15]1([CH3:22])[CH:10]=[CH:11][C:12]([S:16]([O:9][CH2:8][CH2:7][O:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:17])=[O:18])=[CH:13][CH:14]=1

参加物

4

反応物 3

HCID 1049Pyridine2 回HCID 27345953-Methylbenzenesulphonyl chlorideHCID 131875202-(Cyclopentyloxy)ethan-1-ol

生成物 1

HCID 13187521HCID 13187521、化合物収率 73%

実験手順

2-Cyclopentyloxyethanol (4.3 g, 33.1 mmol) in pyridine (18 ml) was added dropwise to a solution of 3-toluenesulphonyl chloride (6.8 g, 35.7 mmol) in pyridine (27 ml) at 5° C. The mixture was allowed to warm to ambient temperature, and stirred overnight. The mixture was poured onto ice containing concentrated hydrochloric acid (46 ml) and the product was extracted with ether. The organic phase was washed with 2M hydrochloric acid, dried (MgSO4) and the solvent removed by evaporation to give 2-cyclopentyloxyethyl 4-toluenesulphonate (6.9 g, 73%) which was used without further purification.

後処理

  1. additionThe mixture was poured onto ice containing concentrated hydrochloric acid (46 ml)
  2. extractionthe product was extracted with ether
  3. washThe organic phase was washed with 2M hydrochloric acid
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-cd77fb3878904afc8634985bf4a3df0d
出典データセット
uspto-grants-2001_02
特許番号
US06184225B2

反応ノート

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