Hydrogen Bromide → 1-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

HRID 634910ノート

反応式

HRID 634910 の反応式
Br.[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:17])[CH3:16])[CH3:3].C([O-])(=O)C.[Na+].Br>O.C(Cl)(Cl)Cl>[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:16])[CH3:17])[CH3:3]

参加物

6

反応物 3

HCID 260Hydrogen BromideHCID 517045Sodium AcetateHCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

生成物 1

HCID 154511031-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6212Chloroform溶媒

実験手順

200 g N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide was suspended in a mixture of 1 l water and 500 ml chloroform. 20% sodium acetate solution was added to this suspension until the pH value reached ca. 5. The organic phase was washed with water, dried over sodium sulfate and evaporated to dryness in a rotary evaporator. A light-brown oil was obtained in this manner. Since the released base decomposes very rapidly, only the required amount of base for the further process was released from the hydrobromide.

後処理

  1. washThe organic phase was washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated to dryness in a rotary evaporator
  4. customA light-brown oil was obtained in this manner

出典と根拠

ORDレコード
ord-20f5b970b52d4e76a10484ba45fb3ed4
出典データセット
uspto-grants-2001_02
特許番号
US06184379B2

反応ノート

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