Benzo(d)thiazol-2-amine → HCID 15086004、化合物

HRID 635858ノート

反応式

HRID 635858 の反応式
C([O:3][C:4]([C:6]1[N:13]2[C:9]([S:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=32)=[N:8][CH:7]=1)=O)C.NC1SC2C=CC=CC=2N=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:8]1[CH:7]=[C:6]([CH2:4][OH:3])[N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[S:10][C:9]=12

参加物

5

反応物 3

HCID 8706Benzo(d)thiazol-2-amineHCID 10890197HCID 10890197、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 15086004HCID 15086004、化合物収率 74%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of imidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester (Formula J-1), (synthesized from 2-aminobenzothiazole by a modification of the procedures described by Fajeli et al., Heterocycles, 1986, 24, 379) (4.5 g) in THF (75 mL) was treated with LiAlH4 (0.91 g) and reacted for 5.25 hours. The suspension was quenched by serial additions of water and 15% sodium hydroxide. The suspension was diluted with THF and filtered. The filtrate was evaporated, the residue was triturated with hexane to yield imidazo[2,1-b]benzothiazole-3-methanol (Formula J-2) (2.77 g, 74%). Crude imidazo[2,1-b]benzothiazole-3-methanol (Formula J-2) was used without further purification.

後処理

  1. customreacted for 5.25 hours
  2. customThe suspension was quenched by serial additions of water and 15% sodium hydroxide
  3. additionThe suspension was diluted with THF
  4. filtrationfiltered
  5. customThe filtrate was evaporated
  6. customthe residue was triturated with hexane

出典と根拠

ORDレコード
ord-8312ea30ccbc4a19a959fcdae9488630
出典データセット
uspto-grants-2001_02
特許番号
US06191124B1

反応ノート

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