Water → 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine

HRID 63605

反応式

HRID 63605 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH2:14])[C:12]#[CH:13].O>C(#N)C>[Cl:8][C:6]1[N:5]=[C:4]([S:9][CH3:10])[N:3]=[C:2]([NH:14][CH2:11][C:12]#[CH:13])[CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 805314,6-Dichloro-2-(methylthio)pyrimidineHCID 239041Propargylamine

生成物 1

HCID 903036916-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine収率 99.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.

後処理

  1. filtrationThen, the formed precipitate was filtered
  2. washwashed several times with cold water
  3. customdried

出典と根拠

ORDレコード
ord-01225f880448429ca0699b60ca00ba14
出典データセット
uspto-grants-2016_09
特許番号
US09447095B2

関連ノート

読み込み中…