N-bromobutanimide → 4-Bromo-2-isopropyl-1-methoxybenzene
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([CH3:11])[CH3:10].[Br:12]N1C(=O)CCC1=O>C(#N)C>[CH:9]([C:4]1[CH:5]=[C:6]([Br:12])[CH:7]=[CH:8][C:3]=1[O:2][CH3:1])([CH3:11])[CH3:10]参加物
4
実験手順
A solution of 2-methoxyisopropyl-benzene (2 g) and N-bromosuccinimide (2.6 g) in acetonitrile (20 mL) was stirred at ambient temperature for 18 h. The reaction was concentrated in vacuo, slurried in carbon tetrachloride and filtered. The filtrate was concentrated in vacuo. The residue was flash chromatographed (5% dichloromethane/hexanes) to afford the title compound as an oil (2.5 g).
後処理
- concentrationThe reaction was concentrated in vacuo
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
- customchromatographed (5% dichloromethane/hexanes)
出典と根拠
- ORDレコード
- ord-8d97fdb2355a424cbaee142aeb8bcfbe
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06194454B1
反応ノート
読み込み中…