Sodium Hydroxide → 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine

HRID 637930

反応式

HRID 637930 の反応式
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH-].[Na+].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1>C(O)C>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][S:3][C:2]2[N:4]=[C:5]([OH:6])[CH:7]=[C:8]([OH:9])[N:1]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 699934-Methyloxybenzyl chlorideHCID 2723628Thiobarbituric acid

生成物 1

HCID 1784917094,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine収率 54.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
60 °C

実験手順

To a suspension of thiobarbituric acid (15 g) in 50% ethanol (180 ml) are added a solution of NaOH (5.1 g) in 50% ethanol (75 ml) and p-methoxybenzyl chloride (18.7 g). The mixture is heated under stirring for 60' at 60° C.; then it is cooled and the solid is filtered by suction, washed with water; then dried over CaCl2, yielding 15 g of 2-p-methoxy-benzylthio-4,6-dihydroxypyrimidine.

後処理

  1. temperatureThe mixture is heated
  2. temperaturethen it is cooled
  3. filtrationthe solid is filtered by suction
  4. washwashed with water
  5. dry with materialthen dried over CaCl2

出典と根拠

ORDレコード
ord-5d6de63010204f47b9d61cc676dd9f97
出典データセット
uspto-grants-1985_12
特許番号
US04559345

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