Hydrochloric Acid → 4-Bromo-6-methoxyquinoline-3-carboxylic acid

HRID 638968ノート

反応式

HRID 638968 の反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16]CC)=[O:15].[OH-].[Na+].Cl>C1COCC1>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49758155Ethyl 4-bromo-6-methoxyquinoline-3-carboxylate

生成物 1

HCID 684531854-Bromo-6-methoxyquinoline-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the ethyl 4-bromo-6-(methyloxy)-3-quinolinecarboxylate (12 g, 38.7 mmol) in THF (120 mL) was added 2N NaOH (45 mL, 90 mmol) dropwise over 15 min. The reaction solution was stirred for 24 h and then neutralized with 2N HCl (pH 6). The THF was removed in vacuo and the resulting aqueous solution was acidified to pH 2. The product was collected by filtration and washed with water and fully dried under vacuum (48 h). Isolated 10.8 g (100%).

後処理

  1. customThe THF was removed in vacuo
  2. filtrationThe product was collected by filtration
  3. washwashed with water
  4. customfully dried under vacuum (48 h)
  5. customIsolated 10.8 g (100%)

出典と根拠

ORDレコード
ord-fd7ccc8ad6a247368853a454134c76ac
出典データセット
uspto-grants-2010_04
特許番号
US07691850B2

反応ノート

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