Tetrahydrofuran → n-(2-(1,3-Dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide

HRID 639353ノート

反応式

HRID 639353 の反応式
ClC([O:4][CH2:5][CH3:6])=O.[O:7]1[CH2:11][CH2:10][O:9][CH:8]1[C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1N.C([N:23]([CH2:26]C)CC)C.C1C[O:31]CC1>>[O:7]1[CH2:11][CH2:10][O:9][CH:8]1[C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1[CH2:6][CH2:5][O:4][NH:23][CH:26]=[O:31]

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 153389082-(1,3-Dioxolan-2-yl)-4-methoxyaniline

生成物 1

HCID 131728036n-(2-(1,3-Dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide

実験手順

Ethyl chloroformate (1.2 eq) was added to 2-(1,3-dioxolan-2-yl)-4-methoxyphenylamine (1eq) and triethyl amine (1.2 eq) in THF at 0° C. The reaction was completed instantaneously. The mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated to give N-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide as a yellow solid in quantitative yield.

後処理

  1. concentrationThe mixture was concentrated
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was washed with brine
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-319bb24a285f455989ec0ff3895bfdf0
出典データセット
uspto-grants-2010_04
特許番号
US07691866B2

反応ノート

読み込み中…