Water → 1-Cyano-2-(2-ethoxycarbonylethyl)-3,4-dihydronaphthalene

HRID 6400

反応式

HRID 6400 の反応式
[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=O)=[O:5])[CH3:2].[C:19](P(=O)(OCC)OCC)#[N:20].[C-]#N.[Li+].O>C1COCC1.CN(C=O)C>[C:19]([C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:16][CH2:17][C:8]=1[CH2:7][CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])#[N:20]

参加物

7

反応物 4

HCID 962WaterHCID 75478Lithium cyanideHCID 76257Diethyl cyanophosphonateHCID 221045592-(2-Ethoxycarbonylethyl)-3,4-dihydro-1(2H)-naphthalenone

生成物 1

HCID 197933031-Cyano-2-(2-ethoxycarbonylethyl)-3,4-dihydronaphthalene収率 64.2%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-(2-Ethoxycarbonylethyl)-3,4-dihydro-1(2H)-naphthalenone (19.7 g, 80 mmol), from Step 1, was dissolved in 200 mL of dry THF and diethyl cyanophosphonate (23.6 mL, 160 mmol), commercially available from Aldrich Chemical Company, was added, followed by 160 mL of a 0.5M solution of lithium cyanide in DMF. The reaction mixture was stirred at ambient temperature overnight and then poured into water. The aqueous mixture was extracted with three portions of diethyl ether. The ether extracts were dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was dissolved in 400 mL of toluene and 20 g of p-toluenesulfonic acid was added. The reaction mixture was heated at reflux for 3 h and allowed to cool to ambient temperature. The toluene solution was washed with 5% aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel eluted with 10% ethyl acetate in hexane to give 13.1 g (64.2% yield) of the title compound; MS DCl--NH3 M/Z: 273 (M+NH4)+.

後処理

  1. extractionThe aqueous mixture was extracted with three portions of diethyl ether
  2. dry with materialThe ether extracts were dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. dissolutionThe residue was dissolved in 400 mL of toluene
  6. addition20 g of p-toluenesulfonic acid was added
  7. temperatureThe reaction mixture was heated
  8. temperatureat reflux for 3 h
  9. temperatureto cool to ambient temperature
  10. washThe toluene solution was washed with 5% aqueous sodium bicarbonate
  11. dry with materialdried over anhydrous magnesium sulfate
  12. filtrationfiltered
  13. concentrationconcentrated in vacuo
  14. customThe residue was purified by chromatography on silica gel
  15. washeluted with 10% ethyl acetate in hexane

出典と根拠

ORDレコード
ord-6af1fdb47b964a16a7ec980db7c96d8b
出典データセット
uspto-grants-1993_09
特許番号
US05248677

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