Cyclamate → Cyclohexylsulfamyl chloride
反応式
[CH:1]1([NH:7][S:8](=[O:11])(=O)[OH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)(Cl)[Cl:13]>C1(C)C=CC=CC=1>[CH:1]1([NH:7][S:8]([Cl:13])(=[O:11])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
Under a nitrogen atmosphere, a solution of N-cyclohexylsulfamic acid (50 g, 279 mmol) and PCl5 (58.1 g, 279 mmol) in 150 mL of toluene is very gently warmed up to 100° C. and maintained at that temperature for 1 hour. Distillation of the solution yields N-cyclohexylsulfamoyl chloride as a colorless solid (45.5 g, 82%).
後処理
- temperaturemaintained at that temperature for 1 hour
- distillationDistillation of the solution
出典と根拠
- ORDレコード
- ord-ade2508b1acf415787124703329b534f
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691929B2
反応ノート
読み込み中…