2,4-Dimethylpyridine → 2,4-Dimethylpyridine 1-oxide
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH3:7])=[CH:3][C:2]=1[CH3:8].ClC1C=C(C=CC=1)C(OO)=[O:14].S([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:8][C:2]1[CH:3]=[C:4]([CH3:7])[CH:5]=[CH:6][N+:1]=1[O-:14]参加物
5
実験手順
To a solution of 2,4-lutidine (2.0 g, 18.7 mmol) in methylene chloride (100 mL) was added 3-chloroperoxybenzoic acid (5.07 g, 29.4 mmol), which was stirred for 20 minutes at room temperature. A small amount of saturated aqueous sodium hydrogen sulfite solution was added to the reaction solution, and the organic layer was separated after vigorous stirring. This organic layer was washed with 5 N aqueous sodium hydroxide solution (5.9 mL), and dried over anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure to obtain the title compound (1.54 g, 66.9%). The title compound was used in the following reaction without being purified.
後処理
- customthe organic layer was separated after vigorous stirring
- washThis organic layer was washed with 5 N aqueous sodium hydroxide solution (5.9 mL)
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under a reduced pressure
出典と根拠
- ORDレコード
- ord-1b4146d5e3d94115ada3963dbb2d5206
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691882B2
反応ノート
読み込み中…