Dimethylamine → Indole, 3-((dimethylamino)methyl)-7-nitro-
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2)([O-:3])=[O:2].[CH3:13][NH:14][CH3:15].[CH2:16]=O.[OH-].[Na+]>O>[CH3:13][N:14]([CH3:16])[CH2:15][C:9]1[C:8]2[C:12](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[NH:11][CH:10]=1参加物
6
実験手順
A mixture of 7-nitro-1H-indole (3 g, 18.5 mmol), 40% aqueous dimethylamine (3.12 mL, 27.7 mmol) and 37% aqueous formaldehyde (1.57 mL, 19.3 mmol) was stirred for three days at ambient temperature. The reaction mixture was diluted with H2O (20 mL) followed 15% aqueous NaOH (200 mL) and extracted with CHCl3 (3×200 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound in sufficient purity for use in the next step. MS: m/z=181 (M+1).
後処理
- extractionextracted with CHCl3 (3×200 mL)
- dry with materialThe combined organic extracts were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-4172bf92b7a34ba9b6fb482f83652f4e
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07696192B2
反応ノート
読み込み中…