(4-Nitrophenyl)acetic acid → HCID 178526605、化合物

HRID 641786

反応式

HRID 641786 の反応式
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[N+:10]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20](O)=O)=[CH:15][CH:14]=1)([O-:12])=[O:11].[OH-].[Na+]>>[Cl:9][C:3]1[C:2]2[NH:1][C:20]([CH2:19][C:16]3[CH:15]=[CH:14][C:13]([N+:10]([O-:12])=[O:11])=[CH:18][CH:17]=3)=[N:8][C:7]=2[CH:6]=[CH:5][N:4]=1

参加物

4

反応物 3

HCID 4661(4-Nitrophenyl)acetic acidHCID 14798Sodium HydroxideHCID 2857362-Chloropyridine-3,4-diamine

生成物 1

HCID 178526605HCID 178526605、化合物収率 76%

実験手順

2.1 A solution of 1.44 g of 3,4-diamino-2-chloropyridine and 9.06 g of (4-nitrophenyl)acetic acid in 10 ml of polyphosphoric acid is stirred at 80° for 16 hours. The mixture is subsequently poured into ice-water, neutralised using NaOH, the deposited crystals are separated off and subjected to conventional work-up. The organic phase yields 2.2 g of 4-chloro-2-(4-nitrophenylmethyl)-3H-imidazo[4,5-c]pyridine (“4”).

後処理

  1. customthe deposited crystals are separated off

出典と根拠

ORDレコード
ord-f84631e2ee1f4c819e853d1652d6304a
出典データセット
uspto-grants-2010_04
特許番号
US07696224B2

関連ノート

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