4-Methylmorpholine → Methyl 4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoate

HRID 642147

反応式

HRID 642147 の反応式
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:4][C:3]=2[O:2]1.CN1CCOCC1.C(OC(Cl)=O)C(C)C.[NH2:30][C:31]1[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=1>C1COCC1.CCOCC>[O:9]1[C:8]2[CH:7]=[CH:6][C:5]([CH2:10][CH2:11][C:12]([NH:30][C:31]3[CH:32]=[CH:33][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:39][CH:40]=3)=[O:14])=[CH:4][C:3]=2[O:2][CH2:1]1

参加物

7

反応物 4

HCID 79724-MethylmorpholineHCID 12082Methyl 4-aminobenzoateHCID 62365Isobutyl chloroformateHCID 648103-(Benzodioxol-5-yl)propionic acid

生成物 1

HCID 9945244Methyl 4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoate収率 62%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 3-(3,4-methylenedioxyphenyl)-propionic acid (501 mg, 2.58 mmol) in anhydrous THF (10 mL) were added N-methylmorpholine (0.28 mL, 2.58 mmol) and isobutylchloroformate (0.33 mL, 2.58 mmol) at 0° C. After 30 min, at 0° C., a solution of methyl 4-aminobenzoate (390 mg, 2.58 mmol) in anhydrous THF (2 mL) was added to the reaction mixture. After 30 min the temperature was allowed to warm up to rt and stir for 24 hrs. After extraction with EtOAc (100 mL), washing with HCl (0.1 N, 50 mL) and a saturated aqueous solution of NaHCO3 (50 mL), the organic layer was dried over sodium sulfate and evaporated under vacuo to give a solid. The residue was taken up in Et2O, filtrated and washed with Et2O gave the title compound as a white solid (62%) in 99.4% purity by HPLC (MaxPlot detection between 230 and 400 nm).

後処理

  1. waitAfter 30 min the temperature was allowed
  2. extractionAfter extraction with EtOAc (100 mL)
  3. washwashing with HCl (0.1 N, 50 mL)
  4. dry with materiala saturated aqueous solution of NaHCO3 (50 mL), the organic layer was dried over sodium sulfate
  5. customevaporated under vacuo
  6. customto give a solid
  7. filtrationfiltrated
  8. washwashed with Et2O

出典と根拠

ORDレコード
ord-022d783b1f5d4d81be1e8acae2189d65
出典データセット
uspto-grants-2010_04
特許番号
US07696231B2

関連ノート

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