反応式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([Mg]Br)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]([BH3-])#[N:16].[Na+].CN(C)P([N:26]([CH3:28])[CH3:27])(N(C)C)=O>>[CH:4]1[CH:3]=[CH:2][C:1]([C:7]2[CH:12]=[CH:11][C:10]([CH:7]([N:26]3[CH:27]=[N:16][CH:15]=[CH:28]3)[C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:9][CH:8]=2)=[CH:6][CH:5]=1参加物
4
実験手順
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
出典と根拠
- ORDレコード
- ord-7a547f5ad390462badb558c0499cc0bc
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- USRE041254E1
関連ノート
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