ビホナゾール

4.77

4.77

2.45e-03 g/L

0.7 [ug/mL] (The mean of the results at pH 7.4)

184.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

171.48 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]；177.23 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 72 reports by companies from 4 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

D01AC10

D - Dermatologicals；D01 - Antifungals for dermatological use；D01A - Antifungals for topical use；D01AC - Imidazole and triazole derivatives；D01AC10 - Bifonazole

QD - Dermatologicals；QD01 - Antifungals for dermatological use；QD01A - Antifungals for topical use；QD01AC - Imidazole and triazole derivatives；QD01AC10 - Bifonazole

Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.